產品名稱：Polyclonal Anti- Annexin A1 antibody
- 產品編號
- BTL1028
- 產品規格
- 100ug
- 價格
- 558 .00
- 來源
- Rabbit
- 交叉反應
- Human, monkey, dog
- 免 疫 原
- A synthetic peptide (conjugated to KLH) corresponding to N-terminal residues of human Annexin A1.
- 產品簡介
- Isotype IgG
Host Rabbit
Reactivity Human, monkey, dog
Specificity Detect endogenous level of total Annexin A1 protein.
- 產品別名
- -
- 產品成分
- -
- 檢測范圍
- -
- 檢測樣品
- -
- 產品應用
- WB(1:1000)
- 保存條件
- -20°C一年,避免反復凍融。
- 背景資料
- Annexin A1 / Annexin I also known as lipocortin I is a protein that in humans is encoded by the ANXA1 gene. Annexin I belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Annexin I has been of interest for use as a potential anticancer drug. It inhibits the NF-κB signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis. ANXA1 inhibits the activation of NF-κB by binding to the p65 subunit.
- 參考資料
- 1. Wallner BP, Mattaliano RJ, Hession C, Cate RL, Tizard R, Sinclair LK, Foeller C, Chow EP, Browing JL, Ramachandran KL (1986). "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity". Nature 320 (6057): 77–81. 2. Zhang Z, Huang L, Zhao W, Rigas B (March 2010). "Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo". Cancer Res. 70 (6): 2379–88.
